Relationship between eye symptoms and blepharospasm: A multicenter case–control study
Identifieur interne : 003764 ( Main/Exploration ); précédent : 003763; suivant : 003765Relationship between eye symptoms and blepharospasm: A multicenter case–control study
Auteurs : Davide Martino [Italie] ; Giovanni Defazio [Italie] ; Giovanni Alessio [Italie] ; Giovanni Abbruzzese [Italie] ; Paolo Girlanda [Italie] ; Michele Tinazzi [Italie] ; Giovanni Fabbrini [Italie] ; Lucio Marinelli [Italie] ; Giovanni Majorana [Italie] ; Maria Buccafusca [Italie] ; Laura Vacca [Italie] ; Paolo Livrea [Italie] ; Alfredo Berardelli [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Age of Onset, Aged, Blepharospasm, Blepharospasm (physiopathology), Case control study, Case-Control Studies, Confidence Intervals, Demography, Diagnostic Techniques, Ophthalmological, Dry eye syndrome, Eye Diseases (physiopathology), Female, Humans, Logistic Models, Male, Middle Aged, Multicenter study, Nervous system diseases, Odds Ratio, Questionnaires, Reproducibility of Results, Vision Disorders (physiopathology), age, blepharospasm, dry eye syndrome, ocular symptoms.
- MESH :
Abstract
Although patients with primary blepharospasm (BSP) commonly report experiencing ocular symptoms before the onset of orbicular spasms, the precise frequency and pathogenic role of this subjective ocular discomfort are poorly understood. We conducted a multicenter case–control study to investigate symptoms related to disorders of the anterior segment of the eye, administering a questionnaire to 165 patients with BSP and 180 age‐ and gender‐matched control patients with hemifacial spasm. On a validation sample, our questionnaire yielded high accuracy in detecting eye diseases (predominantly, dry eye syndrome) using detailed ophthalmological examination as the criterion. Logistic regression analysis indicated a significant association between ocular symptoms at disease onset and BSP. Ocular symptoms starting in the year preceding disease onset (short‐latency symptoms) showed a stronger association with BSP than ocular symptoms occurring earlier in time (long‐latency symptoms). The association was stronger when short‐latency symptoms developed from 40 to 59 years of age, whereas this was not observed for long‐latency symptoms. Our findings support the view that eye symptoms associated with BSP result from eye diseases and may be involved in the pathogenesis of BSP. The differential risk of developing BSP, based on age at onset of ocular symptoms, suggests that age and eye diseases may interact in giving rise to BSP. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20635
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1564">1564</biblScope><biblScope unit="page" to="1570">1570</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C6ECE7663929456924E76919723DA22C63F35AA8</idno><idno type="DOI">10.1002/mds.20635</idno><idno type="ArticleID">MDS20635</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Blepharospasm</term><term>Blepharospasm (physiopathology)</term><term>Case control study</term><term>Case-Control Studies</term><term>Confidence Intervals</term><term>Demography</term><term>Diagnostic Techniques, Ophthalmological</term><term>Dry eye syndrome</term><term>Eye Diseases (physiopathology)</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multicenter study</term><term>Nervous system diseases</term><term>Odds Ratio</term><term>Questionnaires</term><term>Reproducibility of Results</term><term>Vision Disorders (physiopathology)</term><term>age</term><term>blepharospasm</term><term>dry eye syndrome</term><term>ocular symptoms</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blepharospasm</term><term>Eye Diseases</term><term>Vision Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Case-Control Studies</term><term>Confidence Intervals</term><term>Demography</term><term>Diagnostic Techniques, Ophthalmological</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Questionnaires</term><term>Reproducibility of Results</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term><term>Etude cas témoin</term><term>Etude multicentrique</term><term>Oeil sec syndrome</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although patients with primary blepharospasm (BSP) commonly report experiencing ocular symptoms before the onset of orbicular spasms, the precise frequency and pathogenic role of this subjective ocular discomfort are poorly understood. We conducted a multicenter case–control study to investigate symptoms related to disorders of the anterior segment of the eye, administering a questionnaire to 165 patients with BSP and 180 age‐ and gender‐matched control patients with hemifacial spasm. On a validation sample, our questionnaire yielded high accuracy in detecting eye diseases (predominantly, dry eye syndrome) using detailed ophthalmological examination as the criterion. Logistic regression analysis indicated a significant association between ocular symptoms at disease onset and BSP. Ocular symptoms starting in the year preceding disease onset (short‐latency symptoms) showed a stronger association with BSP than ocular symptoms occurring earlier in time (long‐latency symptoms). The association was stronger when short‐latency symptoms developed from 40 to 59 years of age, whereas this was not observed for long‐latency symptoms. Our findings support the view that eye symptoms associated with BSP result from eye diseases and may be involved in the pathogenesis of BSP. The differential risk of developing BSP, based on age at onset of ocular symptoms, suggests that age and eye diseases may interact in giving rise to BSP. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name></noRegion><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name><name sortKey="Alessio, Giovanni" sort="Alessio, Giovanni" uniqKey="Alessio G" first="Giovanni" last="Alessio">Giovanni Alessio</name><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Buccafusca, Maria" sort="Buccafusca, Maria" uniqKey="Buccafusca M" first="Maria" last="Buccafusca">Maria Buccafusca</name><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name><name sortKey="Livrea, Paolo" sort="Livrea, Paolo" uniqKey="Livrea P" first="Paolo" last="Livrea">Paolo Livrea</name><name sortKey="Majorana, Giovanni" sort="Majorana, Giovanni" uniqKey="Majorana G" first="Giovanni" last="Majorana">Giovanni Majorana</name><name sortKey="Marinelli, Lucio" sort="Marinelli, Lucio" uniqKey="Marinelli L" first="Lucio" last="Marinelli">Lucio Marinelli</name><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name><name sortKey="Vacca, Laura" sort="Vacca, Laura" uniqKey="Vacca L" first="Laura" last="Vacca">Laura Vacca</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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